منابع مشابه
Tight blood glucose control with insulin in the ICU: facts and controversies.
Recently, the concept that stress hyperglycemia in critically ill patients is an adaptive, beneficial response has been challenged. Two large randomized studies demonstrated that maintenance of normoglycemia with intensive insulin therapy substantially prevents morbidity and reduces mortality in these patients. Since then, questions have been raised about the efficacy in general and in specific...
متن کاملMoving beyond tight glucose control to safe effective glucose control
The impressive benefits related to the use of tight glucose control by intensive insulin therapy have not been reproduced until now in multicenter large-scale prospective randomized trials. Although the reasons for these failures are not entirely clear, we suggest the use of a stepwise approach - Safe, Effective Glucose Control - that will essentially target an intermediate blood glucose level....
متن کاملGlucose control in the ICU--how tight is too tight?
For the past decade, hospitals have focused on the inpatient management of hyperglycemia, particularly in the intensive care unit (ICU). Extensive observational data have shown a consistent, almost linear relationship between blood glucose levels in hospitalized patients and adverse clinical outcomes, even in patients without established diabetes.1 It has never been entirely clear, however, whe...
متن کاملTight glucose control: sweet or sour?
Introduction: The debate about the potential benefi ts of tight glucose control in intensive care patients has been ongoing since the exciting initial single-center study by Van den Berghe et al. [1], which demonstrated reduced mortality in patients managed according to a protocol aimed at maintaining blood glucose between 80 and 110 mg/dL compared with the then-standard goal of less than 215 m...
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ژورنال
عنوان ژورنال: Expert Review of Endocrinology & Metabolism
سال: 2008
ISSN: 1744-6651,1744-8417
DOI: 10.1586/17446651.3.3.295